' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 7 Researches
7.4
USERS' SCORE
Very Good
Based on 6 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**
Top Medical Research Studies
9
Eicosapentaenoic acid alleviates back pain
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Strong relevance to back pain
We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
Read More
9
Eicosapentaenoic acid aids pain relief
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Study directly assesses EPA's effects
We conducted a thorough investigation into how eicosapentaenoic acid (EPA) could relieve chronic low-back and knee pain in adults. The study was carefully structured as a randomized, double-blind, placebo-controlled trial, which helps ensure that the findings are reliable and unbiased.
Our participants, totaling 120 adults who had been suffering from pain in their low back and knees for at least three months, were divided into two groups. One group received a daily dose of 594 mg of l-serine combined with 149 mg of EPA, while the other group received a placebo. Over the course of eight weeks, we tracked their progress using various pain measurement tools.
The results were promising, showing that both l-serine and EPA together led to meaningful reductions in pain scores. This suggests that including EPA in treatment plans could be beneficial for those suffering from persistent low-back pain.
Our trial highlighted the importance of this combination in pain relief, particularly for chronic conditions. The findings from this study hold potential for guiding future treatments aimed at enhancing the quality of life for many suffering from chronic pain.
Our participants, totaling 120 adults who had been suffering from pain in their low back and knees for at least three months, were divided into two groups. One group received a daily dose of 594 mg of l-serine combined with 149 mg of EPA, while the other group received a placebo. Over the course of eight weeks, we tracked their progress using various pain measurement tools.
The results were promising, showing that both l-serine and EPA together led to meaningful reductions in pain scores. This suggests that including EPA in treatment plans could be beneficial for those suffering from persistent low-back pain.
Our trial highlighted the importance of this combination in pain relief, particularly for chronic conditions. The findings from this study hold potential for guiding future treatments aimed at enhancing the quality of life for many suffering from chronic pain.
Read More
9
EPA may protect discs from degeneration
Omega-3 Fatty Acid Supplementation Reduces Intervertebral Disc Degeneration.
High relevance to treatment effectiveness
We aimed to explore how eicosapentaenoic acid (EPA), an omega-3 fatty acid, can impact intervertebral disc degeneration, which is a common cause of lower back pain. In the study, we used Sprague Dawley rats that had their lumbar discs punctured to induce degeneration. After the surgery, the rats were split into two groups: one received a daily diet enriched with EPA and docosahexaenoic acid (DHA), while the other group followed a standard diet.
After a month of the omega-3 supplementation, we noticed a significant drop in specific blood markers indicating inflammation. By the end of the two-month period, advanced imaging techniques and tissue analysis revealed that the rats on the omega-3 diet had maintained better hydration and displayed less damage to their intervertebral discs compared to the control group.
These findings suggest that incorporating eicosapentaenoic acid into the diet could reduce the inflammation linked to disc degeneration, potentially offering a protective effect against the progression of back pain. This research opens pathways to exploring omega-3s as a viable treatment option for people suffering from chronic back issues.
After a month of the omega-3 supplementation, we noticed a significant drop in specific blood markers indicating inflammation. By the end of the two-month period, advanced imaging techniques and tissue analysis revealed that the rats on the omega-3 diet had maintained better hydration and displayed less damage to their intervertebral discs compared to the control group.
These findings suggest that incorporating eicosapentaenoic acid into the diet could reduce the inflammation linked to disc degeneration, potentially offering a protective effect against the progression of back pain. This research opens pathways to exploring omega-3s as a viable treatment option for people suffering from chronic back issues.
Read More
Most Useful Reviews
9.5
Joint pain relief
I drank two capsules each morning with breakfast for three weeks. I've noticed increased endurance during cardio workouts and no knee pain, which was a previous issue during lunges and squats. This product has worked well for me and my husband, with no mouth or stomach discomfort experienced. I highly recommend it!
Read More
8.3
Reduced back pain
This is my first omega product at 40+. I took it consistently, starting with one capsule and then moving to two daily. After two weeks, I experienced my first month without back pain. I can drink it easily without any regurgitation.
Read More
9.5
Knee pain relief
This Omega-3 has been excellent for me. I tried others, but Natrol's is the best. Previously, I had knee pain during gym training. After a month of taking Omega, the pain disappeared even as I increased my training load. It has truly made a difference.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 7 Researches
7.4
9
Eicosapentaenoic acid alleviates back pain
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Strong relevance to back pain
We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
Read More
9
Eicosapentaenoic acid aids pain relief
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Study directly assesses EPA's effects
We conducted a thorough investigation into how eicosapentaenoic acid (EPA) could relieve chronic low-back and knee pain in adults. The study was carefully structured as a randomized, double-blind, placebo-controlled trial, which helps ensure that the findings are reliable and unbiased.
Our participants, totaling 120 adults who had been suffering from pain in their low back and knees for at least three months, were divided into two groups. One group received a daily dose of 594 mg of l-serine combined with 149 mg of EPA, while the other group received a placebo. Over the course of eight weeks, we tracked their progress using various pain measurement tools.
The results were promising, showing that both l-serine and EPA together led to meaningful reductions in pain scores. This suggests that including EPA in treatment plans could be beneficial for those suffering from persistent low-back pain.
Our trial highlighted the importance of this combination in pain relief, particularly for chronic conditions. The findings from this study hold potential for guiding future treatments aimed at enhancing the quality of life for many suffering from chronic pain.
Our participants, totaling 120 adults who had been suffering from pain in their low back and knees for at least three months, were divided into two groups. One group received a daily dose of 594 mg of l-serine combined with 149 mg of EPA, while the other group received a placebo. Over the course of eight weeks, we tracked their progress using various pain measurement tools.
The results were promising, showing that both l-serine and EPA together led to meaningful reductions in pain scores. This suggests that including EPA in treatment plans could be beneficial for those suffering from persistent low-back pain.
Our trial highlighted the importance of this combination in pain relief, particularly for chronic conditions. The findings from this study hold potential for guiding future treatments aimed at enhancing the quality of life for many suffering from chronic pain.
Read More
9
EPA may protect discs from degeneration
Omega-3 Fatty Acid Supplementation Reduces Intervertebral Disc Degeneration.
High relevance to treatment effectiveness
We aimed to explore how eicosapentaenoic acid (EPA), an omega-3 fatty acid, can impact intervertebral disc degeneration, which is a common cause of lower back pain. In the study, we used Sprague Dawley rats that had their lumbar discs punctured to induce degeneration. After the surgery, the rats were split into two groups: one received a daily diet enriched with EPA and docosahexaenoic acid (DHA), while the other group followed a standard diet.
After a month of the omega-3 supplementation, we noticed a significant drop in specific blood markers indicating inflammation. By the end of the two-month period, advanced imaging techniques and tissue analysis revealed that the rats on the omega-3 diet had maintained better hydration and displayed less damage to their intervertebral discs compared to the control group.
These findings suggest that incorporating eicosapentaenoic acid into the diet could reduce the inflammation linked to disc degeneration, potentially offering a protective effect against the progression of back pain. This research opens pathways to exploring omega-3s as a viable treatment option for people suffering from chronic back issues.
After a month of the omega-3 supplementation, we noticed a significant drop in specific blood markers indicating inflammation. By the end of the two-month period, advanced imaging techniques and tissue analysis revealed that the rats on the omega-3 diet had maintained better hydration and displayed less damage to their intervertebral discs compared to the control group.
These findings suggest that incorporating eicosapentaenoic acid into the diet could reduce the inflammation linked to disc degeneration, potentially offering a protective effect against the progression of back pain. This research opens pathways to exploring omega-3s as a viable treatment option for people suffering from chronic back issues.
Read More
8
Omega-3 reduces menstrual back pain
Effect of Clupeonella grimmi (anchovy/kilka) fish oil on dysmenorrhoea.
High relevance to back pain
We conducted a study to see if omega-3 fatty acids, specifically sourced from Clupeonella grimmi fish oil, could help alleviate back pain associated with dysmenorrhoea. Our research involved a cross-over trial with 36 young women aged 18-22 years.
Participants were split into two groups: one group took 15 mL of fish oil each day, while the other received a placebo. After three months, we switched their treatments.
The results were quite compelling. Women who took the fish oil reported a significant drop in their pain levels on the visual analogue scale, scoring an average of 20.9 compared to 61.8 for those on the placebo. We also noticed a remarkable reduction in both low back and abdominal pain.
Furthermore, the use of fish oil allowed participants to need fewer ibuprofen doses for pain relief, suggesting its effectiveness in managing menstrual-related discomfort. Overall, our findings indicate that eicosapentaenoic acid can play a positive role in easing back pain during menstruation.
Participants were split into two groups: one group took 15 mL of fish oil each day, while the other received a placebo. After three months, we switched their treatments.
The results were quite compelling. Women who took the fish oil reported a significant drop in their pain levels on the visual analogue scale, scoring an average of 20.9 compared to 61.8 for those on the placebo. We also noticed a remarkable reduction in both low back and abdominal pain.
Furthermore, the use of fish oil allowed participants to need fewer ibuprofen doses for pain relief, suggesting its effectiveness in managing menstrual-related discomfort. Overall, our findings indicate that eicosapentaenoic acid can play a positive role in easing back pain during menstruation.
Read More
7
EPA proves beneficial for back pain
Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain.
Directly addresses EPA's effects
We explored how eicosapentaenoic acid (EPA), a key ingredient in fish oil, can help alleviate back pain as an alternative to traditional nonsteroidal anti-inflammatory drugs (NSAIDs). The backdrop for this investigation stems from the known risks associated with NSAIDs, which can range from gastric ulcers to heart complications. In our assessment, we focused on 250 patients suffering from nonsurgical neck or back pain who were encouraged to take 1200 mg of omega-3 fatty acids daily from fish oil.
After about a month, we gathered feedback via a questionnaire. Among the 125 patients who responded, 60% reported an overall improvement in their pain levels. Interestingly, nearly 59% were able to stop taking their prescribed NSAIDs while using fish oil. Satisfaction was notably high, with 80% of patients expressing contentment with their improvement and 88% wishing to continue the supplement. Furthermore, reports of adverse side effects were minimal, indicating a promising safety profile for fish oil supplements.
Overall, our findings align with existing research suggesting EPA as an effective alternative for managing back pain. It appears that fish oil supplements could serve as a safer, more natural approach to pain relief for individuals looking to reduce their reliance on traditional pain medications.
After about a month, we gathered feedback via a questionnaire. Among the 125 patients who responded, 60% reported an overall improvement in their pain levels. Interestingly, nearly 59% were able to stop taking their prescribed NSAIDs while using fish oil. Satisfaction was notably high, with 80% of patients expressing contentment with their improvement and 88% wishing to continue the supplement. Furthermore, reports of adverse side effects were minimal, indicating a promising safety profile for fish oil supplements.
Overall, our findings align with existing research suggesting EPA as an effective alternative for managing back pain. It appears that fish oil supplements could serve as a safer, more natural approach to pain relief for individuals looking to reduce their reliance on traditional pain medications.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 6 Reviews
7.9
9.5
Joint pain relief
I drank two capsules each morning with breakfast for three weeks. I've noticed increased endurance during cardio workouts and no knee pain, which was a previous issue during lunges and squats. This product has worked well for me and my husband, with no mouth or stomach discomfort experienced. I highly recommend it!
Read More
9.5
Knee pain relief
This Omega-3 has been excellent for me. I tried others, but Natrol's is the best. Previously, I had knee pain during gym training. After a month of taking Omega, the pain disappeared even as I increased my training load. It has truly made a difference.
8.8
Joint health improvement
Omega-3s have improved my joint health and reduced back pain. They prevent osteoporosis and inflammation, alleviating symptoms of arthritis. I've not experienced heartburn or side effects and take them regularly. Good quality fish oil with excellent value for money.
8.3
Reduced back pain
This is my first omega product at 40+. I took it consistently, starting with one capsule and then moving to two daily. After two weeks, I experienced my first month without back pain. I can drink it easily without any regurgitation.
3.8
Acne side effect
I ordered this for myself and my husband. It worked for him, but I developed acne on my back and chest. Upon stopping, the acne disappeared. It seems the product may not have been suitable for me, possibly due to sufficient omega levels.
